Bilateral Ovarian Gonadoblastoma Associated With Foci Of Dysgerminoma : A Case Report And Literature Review
Abstract
Ovarian gonadoblastoma is a rare germ cell tumor commonly associated with dysgenetic gonads and the presence of Y chromosome material. Although generally considered histologically benign, it carries a substantial risk of malignant transformation, most frequently into dysgerminoma.
Case Presentation
We report the case of a 35-year-old woman presenting with bilateral ovarian masses initially suspected to be cystic lesions. Histopathological examination revealed bilateral ovarian gonadoblastoma associated with foci of dysgerminoma. This case is remarkable because of the patient’s adult age, bilateral ovarian involvement, and the absence of apparent phenotypic abnormalities.
Conclusion
This case highlights the importance of systematic histopathological examination of ovarian masses, even when they appear clinically benign. It also emphasizes the need for multidisciplinary management and long-term follow-up because of the risk of malignant transformation and recurrence.
Keywords
Full Text:
PDFReferences
Scully RE. Gonadoblastoma: a review of 74 cases. Cancer. 1970;25(6):1340–56.
Zaloudek C, Norris HJ. Gonadoblastoma and dysgerminoma: a clinicopathologic study. Am J Surg Pathol. 1984;8(3):147–57.
Ulbright TM. Germ cell tumors of the gonads. Mod Pathol. 2005;18(Suppl 2):S61–79.
Cools M, Drop SL, Wolffenbuttel KP, et al. Germ cell tumors in the intersex gonad. Endocr Rev. 2006;27(5):468–84.
Talerman A. Germ cell tumors of the ovary. Curr Opin Obstet Gynecol. 1997;9(1):44–7.
Looijenga LH, Hersmus R, Oosterhuis JW, et al. Tumor risk in disorders of sex development. Best Pract Res Clin Endocrinol Metab. 2007;21(3):480–95.
Kurman RJ, Carcangiu ML, Herrington CS, Young RH. WHO Classification of Tumours of Female Reproductive Organs. Lyon: IARC; 2014.
Arafa M, Salah T, Shaban M, et al. Bilateral gonadoblastoma overgrown by dysgerminoma of the right ovary in a patient with Swyer syndrome. Maedica. 2021;16(4):734-737.
Yilmaz B, Gungor T, Bayramoglu H, et al. Bilateral ovarian gonadoblastoma with coexisting dysgerminoma. J Obstet Gynaecol Res. 2010;36(3):697-700.
Raafey MA, Abduljabbar HS, Al-Hussaini TK, et al. Bilateral gonadoblastoma with dysgerminoma in a phenotypically normal female with 46XX karyotype: report of a rare case and literature review. Cureus. 2020;12(7):e9000.
Yin M, Wang Y, Liu X, et al. Ovarian gonadoblastoma with dysgerminoma in a girl with 46,XX karyotype 17α-hydroxylase/17,20-lyase deficiency: a case report and literature review. Front Endocrinol. 2022;13:989695.
DOI: http://dx.doi.org/10.52155/ijpsat.v58.1.8269
Refbacks
- There are currently no refbacks.
Copyright (c) 2026 Vahatra Joëlle Razafimahefa

This work is licensed under a Creative Commons Attribution 4.0 International License.

















