Updates of Management of Acute Non-Variceal Upper Gastrointestinal Bleeding (ANVUGIB): Review

Maged Naser, Mohamed M. Nasr, Lamia H. Shehata

Abstract


Acute non-variceal upper gastrointestinal bleeding (ANVUGIB) is a frequent medical emergency in clinical practice. While the incidence has substantially reduced, the mortality costs have no longer gone through a comparable reduction in the ultimate few decades, accordingly imparting a substantial challenge. This editorial outlines the key motives and threat elements of ANVUGIB and explores the present day requirements and current updates in hazard evaluation scoring structures for predicting mortality and endoscopic remedies for accomplishing hemostasis. Since ANUVGIB predominantly influences the aged population, the effect of comorbidities may additionally be accountable for the negative outcomes. A thorough drug records is necessary due to the growing use of antiplatelet agents and anticoagulants in the elderly. Early chance stratification performs a fundamental function in identifying the line of administration and predicting mortality. Emerging scoring structures such as the ABC (age, blood tests, co-morbidities) rating exhibit promise in predicting mortality and guiding scientific decisions. While traditional endoscopic remedies stay cornerstone approaches, novel strategies like hemostatic powders and over-the-scope clips provide promising alternatives, in particular in instances refractory to usual modalities. By integrating validated scoring structures and leveraging novel therapeutic modalities, clinicians can decorate affected person care and mitigate the sizable morbidity and mortality related with ANVUGIB.

Keywords


Non-variceal upper gastrointestinal bleeding ; Upper gastrointestinal bleeding; Gastrointestinal bleeding; Risk stratification; Risk evaluation scores; Prognostication; Endoscopy; Esophagogastroduodenoscopy; Endoscopic hemostasis.

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References


- Hearnshaw, Sarah A., et al. "Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit." Gut 60.10 (2011): 1327-1335.‏

- Biecker, Erwin. "Diagnosis and therapy of non-variceal upper gastrointestinal bleeding." World journal of gastrointestinal pharmacology and therapeutics 6.4 (2015): 172.‏

- Almadi, Majid A., et al. "Upper gastrointestinal bleeding: Causes and patient outcomes." Saudi Journal of Gastroenterology 27.1 (2021): 20-27.‏

- Lanas, Angel, et al. "Non-variceal upper gastrointestinal bleeding." Nature reviews Disease primers 4.1 (2018): 1-21.‏

- Wang, Xiao-Juan, et al. "Clinical characteristics of acute non-varicose upper gastrointestinal bleeding and the effect of endoscopic hemostasis." World Journal of Clinical Cases 12.9 (2024): 1597.‏

- Lau, James YW, et al. "Challenges in the management of acute peptic ulcer bleeding." The Lancet 381.9882 (2013): 2033-2043.‏

- Laine, Loren, and Dennis M. Jensen. "Management of patients with ulcer bleeding." Official journal of the American College of Gastroenterology| ACG 107.3 (2012): 345-360.‏

- Laine, Loren, et al. "ACG clinical guideline: upper gastrointestinal and ulcer bleeding." Official journal of the American College of Gastroenterology| ACG 116.5 (2021): 899-917.‏

- Mullady, Daniel K., Andrew Y. Wang, and Kevin A. Waschke. "AGA clinical practice update on endoscopic therapies for non-variceal upper gastrointestinal bleeding: expert review." Gastroenterology 159.3 (2020): 1120-1128.‏

- Gralnek, Ian M., et al. "Endoscopic diagnosis and management of nonvariceal upper gastrointestinal hemorrhage (NVUGIH): European Society of Gastrointestinal Endoscopy (ESGE) Guideline–Update 2021." Endoscopy 53.03 (2021): 300-332.‏

- Barkun, Alan N., et al. "Management of nonvariceal upper gastrointestinal bleeding: guideline recommendations from the International Consensus Group." Annals of internal medicine 171.11 (2019): 805-822.‏

- Custovic, Nerma, et al. "Comparison of Glasgow-Blatchford score and Rockall score in patients with upper gastrointestinal bleeding." Medical Archives 74.4 (2020): 270.‏

- Falcão, Daniela, et al. "The current portrayal of non-variceal upper gastrointestinal bleeding in a portuguese tertiary center." GE-Portuguese Journal of Gastroenterology 28.6 (2021): 392-397.‏

- Asotibe, Jennifer C., et al. "Outcomes of non-variceal upper gastrointestinal bleed stratified by hospital teaching status: insights from the National Inpatient sample." Gastroenterology Research 14.5 (2021): 268.‏

- Naseer, Maliha, et al. "Endoscopic advances in the management of non-variceal upper gastrointestinal bleeding: A review." World journal of gastrointestinal endoscopy 12.1 (2020): 1.‏

- Drini, Musa. "Peptic ulcer disease and non-steroidal anti-inflammatory drugs." Australian prescriber 40.3 (2017): 91.‏

- Yin, Lingling, and Wen Yu. "Retrospective analysis of risk factors for non-variceal upper gastrointestinal bleeding and construction of a nomogram prediction model." American Journal of Translational Research 15.5 (2023): 3385.‏

- Tham, T. C. K., C. James, and M. Kelly. "Predicting outcome of acute non-variceal upper gastrointestinal haemorrhage without endoscopy using the clinical Rockall Score." Postgraduate medical journal 82.973 (2006): 757-759.‏

- Saleem, Nasir, and Colin W. Howden. "Update on the management of Helicobacter pylori infection." Current treatment options in gastroenterology 18 (2020): 476-487.‏

- Lau, Louis HS, and Joseph JY Sung. "Treatment of upper gastrointestinal bleeding in 2020: New techniques and outcomes." Digestive Endoscopy 33.1 (2021): 83-94.‏

- Kim, Min Seong, et al. "Validation of a new risk score system for non-variceal upper gastrointestinal bleeding." BMC gastroenterology 20 (2020): 1-10.‏

- Orpen-Palmer, Josh, and Adrian J. Stanley. "A Review of Risk Scores within Upper Gastrointestinal Bleeding." Journal of clinical medicine 12.11 (2023): 3678.‏

- Blatchford, Oliver, William R. Murray, and Mary Blatchford. "A risk score to predict need for treatment for uppergastrointestinal haemorrhage." The Lancet 356.9238 (2000): 1318-1321.‏

- Rockall, T. A., et al. "Risk assessment after acute upper gastrointestinal haemorrhage." Gut 38.3 (1996): 316-321.‏

- Saltzman, John R., et al. "A simple risk score accurately predicts in-hospital mortality, length of stay, and cost in acute upper GI bleeding." Gastrointestinal endoscopy 74.6 (2011): 1215-1224.‏

- Stanley, Adrian J., et al. "Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study." bmj 356 (2017).‏

- Sung, Joseph JY, et al. "Asia-Pacific working group consensus on non-variceal upper gastrointestinal bleeding: an update 2018." Gut 67.10 (2018): 1757-1768.‏

- Laursen, Stig Borbjerg, et al. "ABC score: a new risk score that accurately predicts mortality in acute upper and lower gastrointestinal bleeding: an international multicentre study." Gut 70.4 (2021): 707-716.‏

- Li, Yajie, et al. "Comparisons of six endoscopy independent scoring systems for the prediction of clinical outcomes for elderly and younger patients with upper gastrointestinal bleeding." BMC gastroenterology 22.1 (2022): 187.‏

- Güven, İbrahim Ethem, et al. "Comparison of urgent and early endoscopy for acute non-variceal upper gastrointestinal bleeding in high-risk patients." Gastroenterología y Hepatología 46.3 (2023): 178-184.‏

- Güven, İbrahim Ethem, et al. "Comparison of urgent and early endoscopy for acute non-variceal upper gastrointestinal bleeding in high-risk patients." Gastroenterología y Hepatología 46.3 (2023): 178-184.‏

- Wuerth, Brandon A., and Don C. Rockey. "Changing epidemiology of upper gastrointestinal hemorrhage in the last decade: a nationwide analysis." Digestive diseases and sciences 63 (2018): 1286-1293.‏

- HAYASHI, TAKAO. "The study on stanch clips for the treatment by endoscopy." Gastroenterological Endoscopy 17.1 (1975): 92-101.‏

- Wang, Thomas J., et al. "Choosing the right through-the-scope clip: a rigorous comparison of rotatability, whip, open/close precision, and closure strength (with videos)." Gastrointestinal Endoscopy 89.1 (2019): 77-86.‏

- Daram, Sumanth R., et al. "Benchtop testing and comparisons among three types of through-the-scope endoscopic clipping devices." Surgical endoscopy 27 (2013): 1521-1529.‏

- Parsi, Mansour A., et al. "Devices for endoscopic hemostasis of nonvariceal GI bleeding (with videos)." VideoGIE 4.7 (2019): 285-299.‏

- Mullady, Daniel K., Andrew Y. Wang, and Kevin A. Waschke. "AGA clinical practice update on endoscopic therapies for non-variceal upper gastrointestinal bleeding: expert review." Gastroenterology 159.3 (2020): 1120-1128.‏

- Laine, Loren, and Kenneth R. McQuaid. "Endoscopic therapy for bleeding ulcers: an evidence-based approach based on meta-analyses of randomized controlled trials." Clinical Gastroenterology and Hepatology 7.1 (2009): 33-47.‏

- Jacques, Jérémie, et al. "Endoscopic haemostasis: an overview of procedures and clinical scenarios." Digestive and liver disease 46.9 (2014): 766-776.‏

- Nulsen, B., and D. M. Jensen. "Hemostasis techniques for non-variceal upper GI hemorrhage: Beyond injection and cautery." Digestive diseases and sciences 67.5 (2022): 1431-1441.‏

- Guedes, Hugo Gonçalo, and Eduardo Guimarães Hourneaux de Moura. "Endoscopic management of complications-ovesco/stent for management of anastomotic leaks: A narrative review." Annals of Esophagus (2022).‏

- Wang, Xiao Jing, et al. "Natural History and Retention Time of Over-the-Scope Clips in Clinical Practice." Techniques and Innovations in Gastrointestinal Endoscopy 24.3 (2022): 262-268.‏

- Li, Xue Jing, and Brian M. Fung. "Advancements in endoscopic hemostasis for non-variceal upper gastrointestinal bleeding." World Journal of Gastrointestinal Endoscopy 16.7 (2024): 376.‏

- Diller, Shane. "Development of a Single Use Device Intended to Wash Blood Clot Debris from a Stent Retriever in the Operating Room." (2020).‏

- Ofosu, Andrew, et al. "Analysis of reported adverse events related to single-use duodenoscopes and duodenoscopes with detachable endcaps." Gastrointestinal Endoscopy 96.1 (2022): 67-72.‏

- Li, Xue Jing, and Brian M. Fung. "Advancements in endoscopic hemostasis for non-variceal upper gastrointestinal bleeding." World Journal of Gastrointestinal Endoscopy 16.7 (2024): 376.‏

- Goenka, Mahesh Kumar, Gajanan Ashokrao Rodge, and Indrajeet Kumar Tiwary. "Endoscopic management with a novel over-the-scope padlock clip system." Clinical Endoscopy 52.6 (2019): 574-580.‏

- Prosst, Ruediger L., and Thomas Kratt. "A randomized comparative trial of OTSC and Padlock for upper GI hemostasis in a standardized experimental setting." Minimally Invasive Therapy & Allied Technologies 26.2 (2017): 65-70.‏

- Faggen, Alec E., et al. "Over-the-scope clips versus standard endoscopic treatment for first line therapy of non-variceal upper gastrointestinal bleeding: systematic review and meta-analysis." Digestive diseases and sciences 68.6 (2023): 2518-2530.‏

- Bapaye, Jay, et al. "Safety and efficacy of over-the-scope clips versus standard therapy for high-risk nonvariceal upper GI bleeding: systematic review and meta-analysis." Gastrointestinal endoscopy 96.5 (2022): 712-720.‏

- Ofosu, Andrew, et al. "Over-the-scope-clips as primary and rescue therapy for non-variceal gastrointestinal bleeding: a systematic review and meta-analysis." Minerva Gastroenterologica e Dietologica 65.1 (2018): 70-76.‏

- Zhong, Chunyu, et al. "Clinical outcomes of over-the-scope-clip system for the treatment of acute upper non-variceal gastrointestinal bleeding: a systematic review and meta-analysis." BMC gastroenterology 19 (2019): 1-11.‏

- Abbas, Daniyal, et al. "Analysis of Reported Adverse Events Related to Over-the-Scope Clips: A MAUDE Database Analysis." Techniques and Innovations in Gastrointestinal Endoscopy 25.2 (2023): 106-112.‏

- Kobara, Hideki, et al. "Outcomes of gastrointestinal defect closure with an over-the-scope clip system in a multicenter experience: an analysis of a successful suction method." World Journal of Gastroenterology 23.9 (2017): 1645.‏

- Mercky, Pascale, et al. "Usefulness of over‐the‐scope clipping system for closing digestive fistulas." Digestive Endoscopy 27.1 (2015): 18-24.‏

- Laine, Loren, et al. "ACG clinical guideline: upper gastrointestinal and ulcer bleeding." Official journal of the American College of Gastroenterology| ACG 116.5 (2021): 899-917.‏

- Dhar, Jahnvi, et al. "Hemostatic powders and gels in gastrointestinal endoscopy: current perspective and future recommendations." Expert Review of Gastroenterology & Hepatology 17.11 (2023): 1061-1065.‏

- Yau, Alan Hoi Lun, et al. "Safety and efficacy of Hemospray® in upper gastrointestinal bleeding." Canadian Journal of Gastroenterology and Hepatology 28.2 (2014): 72-76.‏

- Johnston, James L., et al. "Clinical Evidence Supporting FDA Clearance of First-of-a-Kind Therapeutic Devices via the De Novo Pathway Between

- Paoluzi, Omero Alessandro, et al. "Hemostatic Powders in Non-Variceal Upper Gastrointestinal Bleeding: The Open Questions." Medicina 59.1 (2023): 143.‏

- Li, Xue Jing, and Brian M. Fung. "Advancements in endoscopic hemostasis for non-variceal upper gastrointestinal bleeding." World Journal of Gastrointestinal Endoscopy 16.7 (2024): 376.‏

- Varela Rey, Iria. Formulación Magistral y Digitalización: dos herramientas clave de la Farmacia Hospitalaria para la Innovación en Salud. Diss. 2024.‏

- Beyna, Torsten, et al. "NOVEL HEMOSTATIC SYSTEM CONFIRMED TO BE SAFE AND EFFECTIVE FOR THE TREATMENT OF GASTROINTESTINAL BLEEDING." Gastrointestinal Endoscopy 97.6 (2023): AB774.‏

- Seong, Gyeol, et al. "UI-EWD hemostatic powder in the management of refractory lower gastrointestinal bleeding: a multicenter study." Scandinavian Journal of Gastroenterology (2024): 1-6.‏

- Gil, Eun Seok, Elton Aleksi, and Lisa Spirio. "PuraStat RADA16 self-assembling peptide reduces postoperative abdominal adhesion formation in a rabbit cecal sidewall injury model." Frontiers in Bioengineering and Biotechnology 9 (2021): 782224.‏

- Li, Xue Jing, and Brian M. Fung. "Advancements in endoscopic hemostasis for non-variceal upper gastrointestinal bleeding." World Journal of Gastrointestinal Endoscopy 16.7 (2024): 376.‏

- Silva, Ana Maria Marques Nunes da. Relatório de Estágio e Monografia intitulada" Dispositivo médico à base de plantas medicinais, com atividade hemostática para hemofílicos. Sim ou não?. MS thesis. 2023.‏

- Kurt, Mevlut, et al. "Ankaferd Blood Stopper for controlling gastrointestinal bleeding due to distinct benign lesions refractory to conventional antihemorrhagic measures." Canadian Journal of Gastroenterology and Hepatology 24.6 (2010): 380-384.‏

- Bang, Byoung Wook, et al. "CEGP-003 spray has a similar hemostatic effect to epinephrine injection in cases of acute upper gastrointestinal bleeding." Digestive Diseases and Sciences 63 (2018): 3026-3032.‏

- Alali, Ali A., et al. "Topical hemostatic agents in the management of upper gastrointestinal bleeding: a meta-analysis." Endoscopy International Open 11.04 (2023): E368-E385.‏

- Jensen, Dennis M., et al. "Doppler endoscopic probe monitoring of blood flow improves risk stratification and outcomes of patients with severe nonvariceal upper gastrointestinal hemorrhage." Gastroenterology 152.6 (2017): 1310-1318.‏

- Wong, Richard CK. "How to do Doppler Probe EUS for Bleeding." Atlas of Endoscopic Ultrasonography (2022): 186-193.‏

- Satyavada, Sagarika, et al. "Endoscopic doppler probe in the diagnosis and management of upper gastrointestinal hemorrhage." ACG Case Reports Journal 5.1 (2018): e68.‏

- Han, Chaoqun, et al. "Management of non-variceal upper gastrointestinal bleeding: role of endoscopic ultrasound-guided treatments." Therapeutic Advances in Gastroenterology 15 (2022): 17562848211056148.‏

- De Angelis, Claudio Giovanni, et al. "Endoscopic ultrasound-guided treatments for non-variceal upper GI bleeding: a review of the literature." Journal of clinical medicine 9.3 (2020): 866.‏

- De Angelis, Claudio Giovanni, et al. "Endoscopic ultrasound-guided treatments for non-variceal upper GI bleeding: a review of the literature." Journal of clinical medicine 9.3 (2020): 866.‏




DOI: http://dx.doi.org/10.52155/ijpsat.v47.1.6637

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